which of the following equation is used to give rate of drug disdolution from a tablet
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The dissolution rate of poorly wettable drugs is augmented by the addition of a hydrophilic binder. Binder in huge amount amplifies hardness and dwindle rate of dissolution/disintegration tablet. Gelatin as a binder amplifies the rate of dissolution in gastric juice of human more intensely than Na—carboxymethylcellulose or polyethylene glycol 6000. Ameliorated dissolution rate can be obtained in phenobarbital tablets with 10% gelatine, while 20% of gelatin diminishes the rate of dissolution due to the formation of the thick film. Plasdone, the water-soluble granulator, provides a faster rate of dissolution
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