Question

Which of the following factors is known as Chirstmas factor ?

Answer 1

Answer:

This is not an article on what multiplies your cholesterol level over the Christmas period. Or on what brings on - for some - terrible bouts of depression as the festivities draw in on them. But it does have to do with December 25th...in a way. The 'Christmas factor' is a protein whose deficiency was first discovered in the 1950s in a little boy by the name of Stephen Christmas. Also known as factor IX, or FIX, it is involved in blood clotting and its deficiency causes the rare form of congenital male hemophilia: hemophilia B. And coincidences being what they are, the article announcing the discovery of the Christmas factor was actually published in the 1952 Christmas edition of the British Medical Journal!

The art of coagulation is not recent. Primitive forms of the cascade probably existed in jawed vertebrates 450 million years ago. The first recordings of troubles in blood clotting are found in Jewish texts in 200 A.D. The reference is indirect and suggests the exemption of circumcision of any male subject if two of his brothers had already died of bleeding as a consequence of the ritual. The first modern description of haemophilia was made by John Conrad Otto - an American physician - in the very beginning of the 19th century, where he described the predisposition of the male members in certain families to suffer from frequent haemorrhages.

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Answer 2

Also known as factor IX, or FIX, it is involved in blood clotting and its deficiency causes the rare form of congenital male hemophilia: hemophilia B. And coincidences being what they are, the article announcing the discovery of the Christmas factor was actually published in the 1952 Christmas edition of the British ...