Question

Which of the following is appropriate
base for synthesis of aceto acetic ester
from ethyl acetate?
​

Answer 1

Explanation:

Ethyl acetoacetic acid is a building block in organic synthesis since the protons alpha to carbonyl groups are acidic, and the resulting carbanion undergoes nucleophilic substitution.

Answer 2

Answer:

Formation of aceto-acetic-ester by the reaction of sodium ethoxide with ethyl acetate is called claisen condensation.

2CH

3

COC

2

H

5

(i)C

2

H

5

ONa/C

2

H

5

OH

(ii.)H

3

O

+

Ethyl acetoacetate (acetoacetic ester)

CH

3

COCH

2

COOC

2

H

5

+C

2

H

5

OH.