Question

Which of the following is not required during B-oxidation of fatty acids?
(A) FADH
(B) NADH+H
(C) ATP
(D) COASH​

Answer 1

Answer

C) ATP

Explanation

Fatty acids are activated before oxidation, utilizing ATP in the presence of CoA-SH and acyl-CoA synthetase. Long-chain acyl-CoA enters mitochondria bound to carnitine.

Additional information

Regulation of Mitochondrial Fatty Acid Oxidation

Regulation of Mitochondrial Fatty Acid OxidationThe rate of fatty acid oxidation changes in response to the nutritional and hormonal state of the animal. The rate of fatty acid oxidation is high during fasting but low in the fed animal. One cause for this change is the higher concentration of unesterified (free) fatty acids in the circulation of the fasting animal as compared to the concentration in the fed animal. An increased concentration of free fatty acids results in higher rates of cellular uptake and oxidation of fatty acids. In liver, which has high capacities for both synthesizing and oxidizing fatty acids, a reciprocal relationship exists between these two processes. After feeding, when carbohydrates are converted to triacylglycerols, the rate of fatty acid synthesis is high because acetyl-CoA carboxylase is active. This enzyme catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first committed intermediate in fatty acid synthesis. Malonyl-CoA binds to and effectively inhibits CPT I that initiates the uptake of fatty acids by mitochondria.