Question

Which of the following statements is not
correct about apoptosis?

1)Apoptosis of cells induces inflammatory
reaction
2)Apoptosis causes shrinkage of cells
3)Apoptotic cells show nuclear condensation
and fragmentation
4)None of the above​

Answer 1

Solution:

Option 1)Apoptosis of cells induces inflammatory is correct.

Explanation:

Apoptosis, in contrast to necrosis, is not harmful to the host and does not induce any inflammatory reaction. The principal event that leads to inflammatory disease is cell damage, induced by chemical/physical injury, anoxia or starvation.

Answer 2

The statement 1)' Apoptosis of cells induces inflammatory reaction' is not correct about apoptosis.

Apoptosis

• Apoptosis refers to the cell-mediated, programmed death of the damaged cells by various cytotoxic cells like T cells, macrophages etc.
• This in turn helps in getting rid of cells that have aged and are no longer needed. It is particularly important in the immunity of the body as it kills the virus-infected cells.
• However, unlike cell necrosis, cell apoptosis doesn't induce inflammatory reactions. Inflammatory reactions are only induced by infected cells or cells damaged from hypoxia or apoxia.

Incorrect options

• As a result of pore formation in the cell membrane, the cells shrink on apoptosis.
• During apoptosis, the chromatin changes from an active, heterogeneous form to a highly condensed inactive state.

Thus, statement 1) "Apoptosis of cells induces inflammatory reaction" is not true about apoptosis.