Question

Which of the following statements is the closest description of Phase II metabolism?

 Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolitesReactions which occur in the blood supply.Reactions which add a polar functional group to a drugReactions which occur in the gut wall.


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Answer 1

Answer:

Option A is correct i.e. Reactions that add a polar molecule to a functional group already present on a drug or one of its metabolites.

Explanation:

• Option A is correct, the addition of a polar molecule to the functional group already present on a drug occurs in phase II metabolism.
• Option B and D reactions are wrong because the metabolism reactions that occur in the gut wall and blood are phase 1 metabolism reactions and not phase 2.  
• Option C Reactions that add a polar functional group to a drug occur in phase I metabolism.