Question

Which of the following statements is the closest description of Phase 1 metabolism?

Answer 1

Answer:

metabolism- it is sum total of all activities occuring inside our body.

Answer 2

THE PHASE 1 METABOLISM INVOLVES THE REACTION WHICH ADDS A POLAR FUNCTIONAL GROUP TO A DRUG.

Explanation:

• Phase I metabolism involves the introduction of a functional group which increases the polarity of compound on the drug.
• It occurs in most tissues, but primary transfer site of metabolism is in hepatic circulations.
• It also occurs in skin tissues, and lung tissues.
• It can be divided into 3 categories which are oxidation, reduction, and hydrolysis.
• Therefore, the best description is that phase I metabolism adds a polar functional group to a drug.

[Your question is incomplete, but most probably your full question was -Which of the following statements is the closest description of Phase I metabolism?

a) Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.

b) Reactions which occur in the blood supply.

c) Reactions which add a polar functional group to a drug.

d) Reactions which occur in the gut wall. ]