Which of the following terms represent a visual change over time?
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Answer:
CDC researchers and their colleagues successfully reconstructed the influenza virus that caused the 1918-19 flu pandemic, which killed as many as 50 million people worldwide. A report of their work, “Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virusexternal icon“, was published in the October 7, 2005 issue of Science. The work was a collaboration among scientists from CDC, Mount Sinai School of Medicineexternal icon, the Armed Forces Institute of Pathology, and Southeast Poultry Research Laboratoryexternal icon. The following questions and answers describe this important research and related issues.
Background on the Research
What research does the Science article describe? Why is it important?
The Discovery and Reconstruction of the 1918 Pandemic Virus
Lab Worker
Read more on how an expert group of researchers and virus hunters located the lost 1918 virus, sequenced its genome, recreated the virus in a highly safe and regulated laboratory setting at CDC, to study its secrets to better prepare for future pandemics.
This report describes the successful reconstruction of the influenza A (H1N1) virus responsible for the 1918 “Spanish flu” pandemic and provides new information about the properties that contributed to its exceptional virulence. This information is critical to evaluating the effectiveness of current and future public health interventions, which could be used in the event that a 1918-like virus reemerges. The knowledge from this work may also shed light on the pathogenesis of contemporary human influenza viruses with pandemic potential. The natural emergence of another pandemic virus is considered highly likely by many experts, and therefore insights into pathogenic mechanisms could contribute to the development of prophylactic and therapeutic interventions needed to control pandemic viruses.
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