which one there is a genetically
determined ADR.
Answers
Answer:
When a medication causes harm at a standard dose, the patient is said to have suffered an adverse drug reaction (ADR). ... An individual's susceptibility to an ADR is often determined by their genetic make-up, since genes play an important role in modulating the action and biotransformation of drugs.
Genetic factors represent an important source of interindividual variation in drug response. Relatively few adverse drug effects with a pharmacodynamic basis are known, and most of the well characterised inherited traits take the form of genetic polymorphisms of drug metabolism.
Idiosyncratic ADRs are unexpected ADRs that are not dose-related or allergic. They occur in a small percentage of patients given a drug. Idiosyncrasy is an imprecise term that has been defined as a genetically determined abnormal response to a drug, but not all idiosyncratic reactions have a pharmacogenetic cause.