Question

Which reagent is used in Hoffmann bromamide degradation reaction.


Mixture of bromine and potassium hydroxide

Mixture of chlorine and sodium hydroxide

Mixture of bromine and sodium hydroxide

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Answer 1

Mixture of bromine and sodium hydroxide

Answer 2

Answer :-

In Hoffmann bromamide degradation reaction, an amide reacts with bromine and aqueous solution of sodium hydroxide which produces primary amine. This a degradation reaction as primary amine in the product has one carbon lesser than primary amide (in the reactant).

Secondary and tertiary amides don’t show Hoffmann bromamide reaction. Only one unit or molecule of bromine is used in the reaction.

Primary amides show this reaction.

For reaction mechanism, refer the attachment.

Remarks :-

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