Which reagent is used in schiff base reaction with thioglycolic acid
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Synthesis, Characterization and Antimicrobial Evaluation of some Schiff Bases and their Thiazolidinone Products
Article (PDF Available) in Oriental Journal of Chemistry 28(4):1791-1796 · December 2012 with 31 Reads
DOI: 10.13005/ojc/280431
Cite this publication
Desta Gebretekle
Abi Tadesse
Rucha Upadhyay
6.41
Aman Dekebo
19.29Adama Science and Technology University
Abstract
Six isomeric nitro- and methoxy anilines were condensed with vanillin to obtain Schiff's bases. A new series of 2-(4-hydroxy-3-methoxy phenyl)-1-thiazolidinone derivatives were synthesized by the cyclocondensation of Schiff's bases with mercapto acetic acid. The chemical structures of synthesized compounds were confirmed by elemental analysis, molecular weight determination, IR, 1 H & 13 C and DEPT-135 NMR spectral measurements. Antibacterial and antifungal activities were studied in vitro against staphylococcus aurous and Escherichia coli bacteria and Aspergillus niger and Rhizoctoia bataticola fungi by using Ampicillin and Bavistin reference drugs respectively.