Question

which statement describes the role of primase during replication?
1) It catalyses synthesis of leading strand and not lagging strand
2) It functions as holoenzyme that polymerizes in 3 +5 direction
3) It uses an exonulcease activity to remove incorrect nucleotides
4) It catalyses the formation of phosphodiester bond using NTP's as substrate​

Answer 1

Explanation:

Primase synthesizes the RNA primers that are elongated by DNA polymerase. ... Primer RNA is synthesized once to initiate leading strand DNA synthesis and repeatedly on the lagging strand ssDNA to initiate Okazaki fragment synthesis. It is on the lagging strand that primase plays its most important role.