Question

Which structural changes become more favourable when a dna molecule is negatively supercoiled?

Answer 1

n all living cells, DNA is homeostatically underwound relative to its lowest energy conformation, resulting in egative supercoiling. This underwinding of DNA is critical to the metabolism of DNA and, thus, is vital to cell survival. Enzymes called topoisomerases regulate and maintain the supercoiled state of DNA and are critical to the successful replication of the genome. These enzymes are major targets for drugs used in the treatment of bacterial infections and cancer. One puzzling phenomenon of the topoisomerase mechanism is how these enzymes, orders of magnitude smaller than their substrate, can search, recognize and act at a local level to affect global DNA topology. While the homeostatic state of DNA
Differences Between Positively and Negatively Supercoiled DNA that Topoisomerases May Distinguish Differences_Between_Positively_and_Negatively_Supercoiled_DNA_that_Topoisomerases