Question

which technique is use to assay drugs concentration in plasma?​

Answer 1

Answer:

Tis is the answer

Explanation:

chromatography; mass spectrometry. Usually, serum or plasma is used for the measurement of concentration of a drug of interest for the purpose of therapeutic drug monitoring (TDM).

Answer 2

Assay drugs concentration in plasma:

Explanation:

• Agar diffusion bioassay, protein precipitation with subsequent high-performance liquid chromatography (HPLC) testing of the supernatant, and membrane ultrafiltration with HPLC assay of the ultrafiltrate are all methods for determining the quantity of free drug in plasma.

The following method is used to determine the drug concentration in plasma:

• For the detection of indomethacin in plasma, a simple, quick, sensitive, and accurate reversed-phase high performance liquid chromatographic (RP-HPLC) approach has been created.
• Pharmacokinetic (PK) studies are performed to determine therapeutic dosages with a suitable drug concentration versus time profile. The quantity of a drug in a particular volume of blood plasma of the sample is determined by taking a blood sample at any time after drug administration and measuring the amount of the drug in the sample.