Question

which two gases are responsible for ozone depletion?

Answer 1

The depletion of the ozone layer is caused mainly by the increase in emissions of chlorine- and bromine-containing compounds like CFCs, halons, carbontetrachloride, methyl chloroform and methyl bromide. 

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Answer 2

Chlorofluorocarbons (CFCs) and other halogenated ozone depleting substances (ODS) are mainly responsible for man-made chemical ozone depletion. The total amount of effective halogens (chlorine and bromine) in the stratosphere can be calculated and are known as the equivalent effective stratospheric chlorine (EESC)