who discovered the semi conservative model for DNA replication
Answers
Answer:
The Meselson–Stahl experiment is an experiment by Matthew Meselson and Franklin Stahl in 1958 which supported Watson and Crick's hypothesis that DNA replication was semiconservative. In semiconservative replication, when the double stranded DNA helix is replicated, each of the two new double-stranded DNA helices consisted of one strand from the original helix and one newly synthesized. It has been called "the most beautiful experiment in biology."[1] Meselson and Stahl decided the best way to tag the parent DNA would be to change one of the atoms in the parent DNA molecule. Since nitrogen is found in the nitrogenous bases of each nucleotide, they decided to use an isotope of nitrogen to distinguish between parent and newly copied DNA. The isotope of nitrogen had an extra neutron in the nucleus, which made it heavier.
Explanation:
- Watson and Crick outlined a model for DNA replication, later called semi-conservative replication. According to Watson and Crick, in preparation for DNA replication, the two strands of DNA first unwound and separated.
Stahl
- Semi-Conservative DNA Replication: Meselson and Stahl. Watson and Crick's discovery of DNA structure in 1953 revealed a possible mechanism for DNA replication.
Matthew Meselson
- Matthew Meselson and Franklin Stahl's experiments on the replication of DNA, published in PNAS in 1958 ( 2), helped cement the concept of the double helix.