Who many reaction to make aldehyde and ketone in one reaction?
Answers
Grignard reaction with aldehydes and ketones
To produce a primary alcohol, the Grignard reagent is reacted with formaldehyde. Reacting a Grignard reagent with any otheraldehyde will lead to a secondary alcohol. Finally, reacting a Grignard reagent with aketone will generate a tertiary alcohol.The main reactions of the carbonyl group are nucleophilic additions to the carbon‐oxygen double bond. As shown below, this addition consists of adding a nucleophile and a hydrogen across the carbon‐oxygen double bond.
Due to differences in electronegativities, the carbonyl group is polarized. The carbon atom has a partial positive charge, and the oxygen atom has a partially negative charge.Aldehydes are usually more reactive toward nucleophilic substitutions than ketones because of both steric and electronic effects. In aldehydes, the relatively small hydrogen atom is attached to one side of the carbonyl group, while a larger R group is affixed to the other side. In ketones, however, R groups are attached to both sides of the carbonyl group. Thus, steric hindrance is less in aldehydes than in ketones.
Electronically, aldehydes have only one R group to supply electrons toward the partially positive carbonyl carbon, while ketones have two electron‐supplying groups attached to the carbonyl carbon. The greater amount of electrons being supplied to the carbonyl carbon, the less the partial positive charge on this atom and the weaker it will become as a nucleus.