who worked out the sequence of amino acids in the polypeptide chains of the hormone insulin
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ExplanatThe unique sequence of amino acids in a polypeptide chain is its primary structure. For example, the pancreatic hormone insulin has two polypeptide chains, A and B, and they are linked together (Figure 1). The sequences of amino acids in the A and B chains are unique to insulinhe unique sequence for every protein is ultimately determined by the gene encoding the protein. A change in nucleotide sequence of the gene’s coding region may lead to a different amino acid being added to the growing polypeptide chain, causing a change in protein structure and function. In sickle cell anemia, the hemoglobin β chain (a small portion of which is shown in Figure 2) has a single amino acid substitution, causing a change in protein structure and functio
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