whrite a short note on lipids as antigens
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Lipid antigens are of both self and microbial origin. T cells may recognize microbial lipids that are produced during infection and are loaded on CD1 molecules in the endosomal compartment. ... The type of alkyl chain is important to allow binding to different CD1 molecules.
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Lipid antigens are immunogenic for T cells when they are presented by CD1 antigen-presenting molecules that bind lipids. Five CD1 proteins are expressed in humans, whereas only one is expressed in mice. ... This characteristic makes the biology and immunogenicity of lipids different from that of peptides
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