Question

why 3 amino pyridine is easily diajotised compare 2 amino pyridine​

Answer 1

Answer:

Aminopyridine, a potassium channel blocker, increases ACh release at the presynaptic level by prolonging the duration of nerve action potential at central, autonomic, and neuromuscular synapses.

4-Aminopyridine (4-AP) was used for the symptomatic treatment of LEMS in open trials in nine patients, who experienced clinical and electrophysiologic improvement.104 However, seizures occurred in two patients. The threat of serious central nervous system (CNS) side effects has thus limited the use of 4-AP, a drug known to cross the blood–brain barrier and result in epileptogenic effects in animals.