Why addition of ceramics nanopartocles leads to improves the freezing temperature
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Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nano particles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nano particles. This article reviews the state of the art of freeze-drying nano particles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nano particles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.
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