Why are lysosomes also called as suicide bags?
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50 years ago, Christian de Duve introduced the term “suicide bags” to describe lysosomes (1), the organelles containing numerous hydrolases, which were, until the discovery of the ubiquitin-proteasome system, thought to be responsible for the major part of the intracellular turnover of proteins and other macromolecules
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Lysosomes are known as suicide bags of the cell because they contain lytic enzymes capable of digesting cells and unwanted materials.
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When lysosomes burst, the lytic enzymes within the organelle spill all over the cell, rupturing the cell membrane or cell wall and inducing the death of the cell.
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