Question

Why are microdeletions and microinsertions difficult to diagnose?

Answer 1

Because only the chromosomes can be seen in a karyotype, and microdeletions/insertions are mutations at the molecular level, it is virtually impossible to detect such mutations at the chromosomal level.

Answer 2

Answer: Micro deletions and Microinsertion are difficult to diagnose because it occurs at molecular level.

The smallest molecular objects seen inside the body is chromosomes that can be seen through karyotype (number and appearance of chromosomes in nucleus of the Eukatyotic cell)

It is not possible practically to diagnose the genes or the nucleotide bases. Microdeletion or Microinsertation occurs at molecular level (change in the single base pair) which is not possible to be diagnosed.