Question

why are monocytes called antigen presenting cells.Explain in detail ​

Answer 1

The fragment can be incoporated into MHC molecules and then trafficked to the cell surface of monocytes and macrophage and dendritic cells.
This process is called antigen presenting cell.

Answer 2

Answer:

Antigen-presenting cells are monocytes. They can trigger an immunological response by giving the T cell a fragment of an antigen protein.

Explanation:

• Mononuclear phagocyte lineage immature cells include monocytes. They are known as immature phagocytes because they have fewer organelles and enzymes in their cytoplasm than phagocytes do, as well as fewer receptors on their membranes and lower pinocytosis activity.
• The peptide antigens are ingested and presented by antigen-presenting cells on their outer surface in a way that a T lymphocyte can recognize them. For presentation to helper T cells or cytotoxic T lymphocytes, the antigen must be linked to either class II MHC or class I MHC. Helper T cells receive antigen from accessory cells like monocytes and mononuclear phagocytes as well as B lymphocytes, whereas cytotoxic T cells receive antigen from target cells like fibroblasts.
• The monocyte consumes proteins, which are then broken down into short (8–10 amino acid) peptides in acidic endosome vesicles. MHC class II is where these peptides bind. Some of these peptides may be bound and displayed at the cell membrane's surface (termed immunogenic peptides). When T cells have the right T cell receptors, they will attach, become stimulated, and activated, releasing lymphokines such as interleukin 2. These lymphokines activate various cells, such as mononuclear phagocytes, causing them to become microbicidal.

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