Why are neurons not capable of regeneration?
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ᴄᴇɴᴛʀᴀʟ ɴᴇʀᴠᴏᴜs sʏsᴛᴇᴍ ʀᴇɢᴇɴᴇʀᴀᴛɪᴏɴ
ɪᴛ ɪs ʟɪᴍɪᴛᴇᴅ ʙʏ ᴛʜᴇ ɪɴʜɪʙɪᴛᴏʀʏ ɪɴғʟᴜᴇɴᴄᴇs ᴏғ ᴛʜᴇ ɢʟɪᴀʟ ᴀɴᴅ ᴇxᴛʀᴀᴄᴇʟʟᴜʟᴀʀ ᴇɴᴠɪʀᴏɴᴍᴇɴᴛ. ... ᴛʜᴇ ᴇɴᴠɪʀᴏɴᴍᴇɴᴛ ᴡɪᴛʜɪɴ ᴛʜᴇ ᴄɴs, ᴇsᴘᴇᴄɪᴀʟʟʏ ғᴏʟʟᴏᴡɪɴɢ ᴛʀᴀᴜᴍᴀ, ᴄᴏᴜɴᴛᴇʀᴀᴄᴛs ᴛʜᴇ ʀᴇᴘᴀɪʀ ᴏғ ᴍʏᴇʟɪɴ ᴀɴᴅ ɴᴇᴜʀᴏɴs.
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Explanation:
Despite the presence of cells with regenerative capacity, neuroregeneration in the adult brain is limited because of the inhibitory action of the glial cells and an extracellular environment that counteracts the myelin and neuronal repair. For example, glial scar formation inhibits axonal regeneration.
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