Why are there problems in cell division even if there are check points?
Answers
If they're cancer cells, the answer might be yes. Normal cells, however, move through the cell cycle in a regulated way. They use information about their own internal state and cues from the environment around them to decide whether to proceed with cell division. This regulation makes sure that cells don't divide under unfavorable conditions (for instance, when their DNA is damaged, or when there isn't room for more cells in a tissue or organ).
A checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and "decides" whether or not to move forward with division.
There are a number of checkpoints, but the three most important ones are:
The G_1
1
start subscript, 1, end subscript checkpoint, at the G_1
1
start subscript, 1, end subscript/S transition.
The G_2
2
start subscript, 2, end subscript checkpoint, at the G_2
2
start subscript, 2, end subscript/M transition.
The spindle checkpoint, at the transition from metaphase to anaphase.
Explanation:
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