Question

Why can generally only very small, hydrophobic molecules cross the cell membrane by simple diffusion?

Answer 1

Answer:

The lipid bi-layer is the main fabric of the membrane, and its structure creates a semipermeable membrane. The hydrophobic core impedes the diffusion of hydrophilic structures such as ions and polar molecules, but allows hydrophobic molecules, which can dissolve in the membrane, to cross it with ease.

Answer 2

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