Why can piperidine not be used in place of pyridine in the schotten Baumann procedure ? Explain with the structure
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The use of added base to drive the equilibrium in the formation of amides from amines and acid chlorides. The acylation of amines with carboxylic acid chlorides leads to the production of one equivalent acid, which will form a salt with unreacted amine and diminish the yield.
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Piperidine is a secondary amine. So it will undergo acylation by itself. So it cannot be used in place of pyridine.
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