Question

why cant DNA replication not proceed to the regions outside the replication bubble unless topoisomerase binds ahead of each advancing replication fork?

Answer 1

Answer:

Topoisomerase is the enzyme which unzips the two complimentary strands of the DNA

Explanation:

Since each of the strand of the DNA is replicated separately i.e: semi consevatively two strands of DNA must be unzipped and tension at the opening point of the replication fork must be lessened so topoisomersse does the task and makes the replication process an uninterrupted one..

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