Why did smallpox kill a large number of native Americans?
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Smallpox killed a large number of native Americans because of their long isolation, they had no immunity against this disease.
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Explanation:
smallpox was lethal to many native Americans, bringing sweeping epidemics and affecting the same tribes repeatedly. Certain culture and biological traits made Native Americans more susceptible to these diseases. Emphasis placed on visiting the sick lead to the spread of disease through continual contact.
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