Question

why do enzymes not function when they are denatured

Answer 1

Answer:

Most biological substrates lose their biological function when denatured. For example, enzymes lose their activity, because the substrates can no longer bind to the active site, and because amino acid residues involved in stabilizing substrates' transition states are no longer positioned to be able to do so.

Explanation:

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Answer 2

When the optimum temperature increases the enzymes key and lock mechanism is deactivated or stop to work
And enzymes is denatured