Why do individuals deficient of glucose-6-phosphate dehydrogenase have increased resistance to malaria infection?
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As G6PD deficiency leads to increased oxidative stress in red blood cells, this may in turn have a negative influence on the parasite. As such, individuals who possess this mutation have some protection against malaria.
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the person who have glucose 6 phosphate dehydrogenase has disease called sickle cell anaemia.their RBCs are sickle shaped and unable to carry oxygen in them.
malarial parasites live in RBC of human .
due to sickle shaped RBC ,malarial parasite cannot live in it.
so those people evn though attacked by malarial parasite ,do not develop the symptoms of malaria
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