Why does an actin thin filament manage to move continuously during a contraction cycle?
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All of the myosin heads beat synchronously. A single myosin head moves an actin filament about 10 nm in a single power stroke, yet the myosin head itself only experiences a 0.5 nm conformational change.
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For a muscle cell to contract, the sarcomere must shorten. However, thick and thin filaments—the components of sarcomeres—do not shorten. Instead, they slide by one another, causing the sarcomere to shorten while the filaments remain the same length.
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