Question

Why does tissue become insensitive to insulin? ​

Answer 1

Answer:

search for insulin resistance in Google search

Answer 2

That's because of

There are three broad categories of insulin-resistance or insulin-deficient states:

(i) abnormal β-cell secretory product, which results in reduced insulin production in the pancreas;

(ii) insulin antagonists in the blood plasma, due either to counterregulatory hormones or to non-hormonal bodies that affect insulin