why fibers are so called dead cell ?
Answers
Answer:
Fiber cells also develop an extensive cytoskeletal network. Although the cell adhesion molecule, N-cadherin, is found in both epithelial cells and fiber cells, it specifically localizes to fiber cell membranes upon differentiation. N-cadherin also co-localizes with F-actin and β-catenin on the lateral membranes of the hexagonally packed fiber cells. In contrast, N-cadherin associates with γ-catenin at the vertices of the fiber cell hexagons. γ-Catenin also associates with desmoplakin and vimentin intermediate filaments in this N-cadherin-based junctional complex. Lens fiber cells also uniquely express components of intermediate beaded filaments, filensin (CP115) and phakinin (CP49). Proteomic studies have demonstrated an interaction of both filensin and phakinin with AQP0 at the cell membrane. Phakinin and vimentin also associate with lengsin at fiber cell membranes. Lengsin is a lens-specific protein related to glutamine synthase which appears to have been evolutionarily recruited to serve as a lens cytoskeletal protein in vertebrates. In mice, lengsin expression initiates in fiber cells just prior to organelle loss. Interestingly, this is precisely the time when beaded filaments undergo a redistribution from being primarily associated with the plasma membrane to being distributed throughout the cytoplasm. Cytoskeletal remodeling is an essential component of both fiber cell elongation and migration. Networks of F-actin and myosin IIB, predominantly localized at the basal membrane complex, are likely regulated by myosin light-chain kinase and small guanosine triphosphate (GTP)-binding proteins such as Rho. Protrusive lamellipodia-like processes have also been observed on both basal and apical fiber cell tips, suggesting that these cellular extensions may play a direct role in the migration of the ends of the fiber cells.
Explanation:
this is a long Answer
hope it is helpful
Answer:
sorry I don't know sorry for this answer I'm very sorry