Question

Why intramolecular substitution reactions fasterthan intermolecular substitution reaction?

Answer 1

✔✅The use of 2-methylproline means that the anti transition state is much lower in energy than the syn transition state, because it has less steric repulsions from the methyl group. The enamine undergoes and intramolecular nucleophilic substitution reactionsimilar to an SN2 reaction.

Answer 2

Answer:

An intramolecular reaction involves only one molecule that contains both the nucleophile and the electrophile. The reaction is faster because the nucleophile and electrophile are held close together. ... The intramolecular reaction is 5000 times faster than the intermolecular reaction.