Why is calcium passively absorbed in thiazide diuretics?
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Answer:The mechanism of the hypercalcemia may involve the action of thiazide diuretics to increase proximal tubular calcium reabsorption as a secondary consequence of direct action of thiazides on the distal tubule.
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Thiazide diuretics increase calcium reabsorption at the distal tubule. ... Thus, intracellular Ca2+ concentration is decreased, which allows more Ca2+ from the lumen of the tubules to enter epithelial cells via apical Ca2+-selective channels
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