Question

Why is it not possible for an alien DNA to become part of a chromosome anywhere along its length and replicate normally?

Answer 1

Here is the Answer!

The integration of alien DNA is required to become a part of chromosome. As the DNA itself cannot multiply and replicate but rather requires a specific sequence for initiating its replication called origin of replication. Therefore, the alien DNA needs to be joined with the host DNA with the help of enzymes and linked to Ori, so as to be part of chromosome and replicate normally to produce its copies.

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Answer 2

Answer:

Alien DNA cannot become part of the chromosome anywhere along its length and replicate normally because in order to ligate itself to the host chromosome alien DNA requires specific recognition sequences. The sequence should also be close to the origin of replication or Ori where DNA replication starts.

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