Question

Why is it very unlikely for a frameshift mutation to be a silent mutation

Answer 1

Answer is given in Explanation part

Explanation:

• In frameshift mutation there is a addition or deletion of nucleotides that causes changes in the reading frame of triplet codon that result in the addition or deletion of amino acids respectively. In silent mutation third base of the codon is changed, it does not alter sequence of amino acids so the protein remain same as earlier.
• Addition or deletion of amino acid altering structure and function of the protein molecule .
• For example- A DNA sequence is 3'GTGCAATGGGCCAAT5', so the mRNA sequence is 5' CACGUUACCCGGUUA3' Protein sequence is His-Val-Thr-Arg-Leu. if we add two C nucleotides after first G then DNA sequence will be 3'GCCTGCAATGGGCCAAT5', mRNA will be 5'CGGACGUUACCCGGUUA3', protein sequence will be Arg-Thr-Leu-Pro-Gly. so by addition of two nucleotide whole protein is changed. Therefore frameshift mutation can never be silent mutation.