Question

why is muscle lack from glucose-6-phosphatase?

Answer 1

$\huge\mathcal{Answer:}$

Thus, glucose 6-phosphate generated from glycogenolysis and glucogenesis is released from the liver into the circulation for peripheral use. There does not appear to be glucose 6-phosphatase in skeletal muscle; hence, muscle glycogen is not a source of circulating glucose.

Answer 2

Answer:

Thus, the glycogen that muscles store is not usually available for the rest of the body's cells because glucose 6-phosphate cannot cross the sarcolemma unless it is dephosphorylated. The enzyme plays an important role during periods of fasting and when glucose levels are low.

Explanation:

Glucose 6 phosphatase (G6Pase )is an enzyme found in the liver and kidneys that plays an important role of providing glucose during starvation. The main function of this enzyme is to catalyses the last step of both gluconeogenesis and glycogenolysis that is converts glucose 6 phosphate to free glucose and phosphate group. Liver is responsible for close monitoring of relatively constant level of glucose in blood stream.

The G6Pase found in liver, kidney and intestine is named G6Pase-alpha.

Recently a second G6Pase named as G6Pase- Beta , has been found in muscle, which shares similar kinetics of G6Pase-alpha and couples with G6Ptranspoter(G6PT) to form an active G6Pase complex.

Muscle does not contain G6Pase-alpha, but contains G6Pase-beta according to researchers JJShieh etal ( 2004).

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