Why is RNA structure so unstable?
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RNA is susceptible to this base-catalyzed hydrolysis because the ribose sugar in RNA has a hydroxyl group at the 2' position. ... This feature makes RNA chemically unstable compared to DNA, which does not have this 2' -OH group and thus is not susceptible to base-catalyzed hydrolysis.
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RNA is susceptible to this base-catalyzed hydrolysis because the ribose sugar in RNA has a hydroxyl group at the 2' position. This feature makes RNA chemically unstable compared to DNA, which does not have this 2' -OH group and thus is not susceptible to base-catalyzed hydrolysis.
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