Question

why is the formation of frcuctose-1,6- bisphosphate the commited step in glycolysis?​

Answer 1

Explanation:

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Fructose 1,6-bisphosphate, the product of the preceding irreversible step in glycolysis, activates both isozymes to enable them to keep pace with the oncoming high flux of intermediates. ATP allosterically inhibits both the L and the M forms of pyruvate kinase to slow glycolysis when the energy charge is high.