Question

Why lipid soluble hormones use intracellular receptors instead of cell surface bound receptors for cell signaling? Diagrammatically brief out the sequential steps of cell signaling cascade regulating the gene expression by steroid hormones​

Answer 1

Water-soluble hormones are amines and proteins that do not passively diffuse through the cell membrane. Instead, water soluble hormones bind to their respective receptors expressed on the extracellular surface of the target cell membrane. ... Lipid-soluble hormones easily diffuse through the cell membrane. The key difference between internal receptors and cell surface receptors is that internal receptors are present in the cytoplasm and respond to hydrophobic ligands that enter the cell across the plasma membrane while cell surface receptors are present on the cell membrane and respond to external ligands that do not ...Lipid-soluble hormone: A lipophilic hormone that passes through the plasma membrane of a cell, binds to an intracellular receptor, and changes gene expression.receptors?

Intracellular hormone receptors are located inside the cell. Hormones that bind to this type of receptor must be able to cross the cell membrane. Steroid hormones are derived from cholesterol and therefore can readily diffuse through the lipid bilayer of the cell membrane to reach the intracellular receptor