Why males are more effected by haemophilia than females ?
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These disorders affect males more often than females because females have an additional X chromosome that acts as a “back-up.” Because males only have one X chromosome, any mutation in the factor VIII or IX gene will result in hemophilia.
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This means that males only have one copy of most of the genes on the X chromosome, whereas females have 2 copies. Thus, males can have a disease like hemophilia if they inherit an affected X chromosome that has a mutation in either the factor VIII or factor IX gene.
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