Question

Why mitochondrialmembrane impermeability is importent?

Answer 1

The structure of the inner mitochondrial membrane is extensively folded and compartmentalized. The numerous invaginations of the membrane are called cristae, separated by crista junctions from the inner boundary membrane juxtaposed to the outer membrane. Cristae significantly increases the total membrane surface area compared to a smooth inner membrane and thereby the available working space.

The inner membrane creates two compartments. The region between the inner and outer membrane, called the intermembrane space which is largely continuous with the cytosol, and the more sequestered space inside the inner membrane, called matrix.

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Answer 2

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Mitochondria are important organelles for energy production, Ca2+ homeostasis, and cell death. ... In apoptotic and necrotic death, an increase of mitochondrial membrane permeability is considered to be one of the key events, although the detailed mechanism remains to be elucidated