Question

Why n2a neuroblastoma cells used for op toxicity testing?

Answer 1

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❏While we found that the OPs tested cross the model BBB and rapidly affect AChE activity of neuronal/glial co-cultures, often independent of cell toxicity, the endothelium may serve to reduce the toxicity of these substances by metabolic effects, even if it doesn't impede their passage into brain tissue.

Answer 2

Answer :

★ While we found that the OPs tested cross the model BBB and rapidly affect AChE activity of neuronal/glial co-cultures, often independent of cell toxicity, the endothelium may serve to reduce the toxicity of these substances by metabolic effects, even if it doesn't impede their passage into brain tissue.

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