Why nucleophilic substitution in pyridine favours at position-2,4 and 6?
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Hiee...✌️❣️
ᴡʜᴇɴ ᴛʜᴇ ɴᴜᴄʟᴇᴏᴘʜɪʟᴇ ɪꜱ ᴀᴛ ᴛʜᴇ 2 ᴀɴᴅ 4 ᴘᴏꜱɪᴛɪᴏɴꜱ, ᴛʜᴇ ɪɴᴛᴇʀᴍᴇᴅɪᴀᴛᴇ ᴀɴɪᴏɴ ɪꜱ ꜱᴛᴀʙɪʟɪᴢᴇᴅ ʙʏ ᴛʜᴇ ᴇʟᴇᴄᴛʀᴏɴᴇɢᴀᴛɪᴠᴇ ɴɪᴛʀᴏɢᴇɴ ᴀᴛᴏᴍ. ᴛʜɪꜱ ʀᴇꜱᴜʟᴛꜱ ɪɴ ᴀ ᴍᴏʀᴇ ꜱᴛᴀʙʟᴇ ᴀɴɪᴏɴ ᴀꜱ ᴄᴏᴍᴘᴀʀᴇᴅ ᴛᴏ ᴛʜᴇ ɪɴᴛᴇʀᴍᴇᴅɪᴀᴛᴇ ᴀɴɪᴏɴ ᴡʜᴇɴ ᴛʜᴇ ɴᴜᴄʟᴇᴏᴘʜɪʟᴇ ɪꜱ ᴀᴛ ᴛʜᴇ 3 ᴘᴏꜱɪᴛɪᴏɴꜱ.✌️
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due to negative charge act on Ortho and meta position
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