Why patients with severe deficiency of oligosaccharides suffer from diarrhoea?
Answers
Intolerance to carbohydrates is relatively common in childhood, but still poorly recognized and managed. Over recent years it has come to the forefront because of progresses in our knowledge on the mechanisms and treatment of these conditions. Children with intolerance to carbohydrates often present with unexplained signs and symptoms. Here, we examine the most up-to-date research on these intolerances, discuss controversies relating to the diagnostic approach, including the role of molecular analysis, and provide new insights into modern management in the pediatric age, including the most recent evidence for correct dietary treatment.
Keywords: lactose intolerance, fructose malabsorption, sucrase-isomaltase deficiency, glucose-galactose malabsorption, sorbitol intolerance, trehalose intolerance, FODMAPs intolerance, breath test, molecular analysis
1. Introduction
Adverse food reactions (AFR) represent a relevant problem in daily clinical practice, but are poorly recognized and managed. They are common in industrialized countries, where, depending on data collection methods and definitions, they affect up to 20% of the general population