Chemistry, asked by Koikkara2229, 1 year ago

Why phase 1 biotransformation known as synthetic reaction?

Answers

Answered by jewelsaji3
1

Phase І reaction

-Includes oxidative, reductive, and hydrolytic reactions.

-In these types of reactions, a polar group is either introduced or unmasked, so the drug molecule becomes more water-soluble and can be excreted.

-Reactions are non-synthetic in nature and in general produce a more water-soluble and less active metabolites.

-The majority of metabolites are generated by a common hydroxylating enzyme system known as Cytochrome P450.

Similar questions