Why phase 1 biotransformation known as synthetic reaction?
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Phase І reaction
-Includes oxidative, reductive, and hydrolytic reactions.
-In these types of reactions, a polar group is either introduced or unmasked, so the drug molecule becomes more water-soluble and can be excreted.
-Reactions are non-synthetic in nature and in general produce a more water-soluble and less active metabolites.
-The majority of metabolites are generated by a common hydroxylating enzyme system known as Cytochrome P450.
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