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Why prolonged left ventricular ejection in aortic stenosis?

Answer 1

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Left Ventricular Ejection Time in Valvular Aortic StenosisROBERT J. BACHE, M.D. YANG WANG, and M.D.JOSEPH C. GREENFIELDJR.M.D.From the Department of Medicine, Division of Cardiology, Duke University Medical Center, the Veterans Administration Hospital, Durham, North Carolina, and the University of Minnesota Hospitals, Minneapolis, Minnesota.

Originally published1 Mar 1973Circulation. 1973;47:527–533

Abstract

Hemodynamic data obtained at cardiac catheterization from 40 patients with valvular aortic stenosis demonstrated that, although left ventricular ejection time was prolonged, the usual linear inverse relationship between heart rate and ejection time was preserved at a longer than normal mean ejection time. In contrast to this, the direct linear relationship between ejection time and stroke volume which exists in normal human subjects was totally obliterated in patients with aortic stenosis so that ejection time appeared to be totally unrelated to stroke volume. However, the degree of prolongation of left ventricular ejection time above that predicted from stroke volume (ΔLVET) was closely correlated with aortic valve area (AVA), so that aortic valve area could be predicted as AVA = 0.91 – 3.6 ΔLVET within 95% confidence limits of ± 0.16 cm2.


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